Gadavist vs Dotarem

Comparison of Gadovist 75% Standard Dose to Dotarem at

Comparison of Gadovist 75% Standard Dose to Dotarem at Full Standard Dose - Full Text View - ClinicalTrials.gov Comparison of Gadovist 75% Standard Dose to Dotarem at Full Standard Dose (LEADER 75) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators Gadoterate meglumine (Dotarem; Guerbet, Aulnay-sous-Bois, France) and gadobutrol (Gadovist, Bayer Schering Pharma, Berlin, Germany; or Gadavist, Bayer HealthCare Pharmaceuticals, Wayne, New Jersey) were each administered at a single dose of 0.1 mmol/kg of body weight (0.2 mL/kg for gadoterate meglumine, 0.1 mL/kg for gadobutrol) by intravenous.

Comparison of Gadoterate Meglumine and Gadobutrol in the

Dotarem vs Gadobutrol Contrast for Breast MRI - Full Text

In recent years, there have been a number of studies comparing different gadolinium chelates for MR imaging of tumors, particularly for MR imaging of intracranial neoplasms. These have included intraindividual studies that compared gadobenate dimeglumine (MultiHance; Bracco, Milan, Italy) with othe In her review, Dr. Yang raised a concern about the true relative risk of Gadavist (Sections She argued that the number of NSF cases reported for Gadavist is higher than other macrocyclic GBCAs (2 in 6 million vs 1 in for Dotarem)6, which may be due to its lower stabilities (see pKcond in Table 1). The subtle differences in. Gadavist ® is a clear, colorless-to-pale yellow solution containing 1 mmol gadobutrol per milliliter (equivalent to 604.72 mg gadobutrol per mL).. Gadavist ® is supplied in the following sizes:. Ordering Information. Gadavist ® is available through all suppliers currently providing our other imaging products. To establish an account, call Bayer HealthCare LLC's master distributor.

Dotarem (Gadoteric acid) 4. What are Omniscan (gadodiamide) and Magnevist (gadopentetate dimeglumine) used for? Omniscan, the brand name of gadodiamide, is a gadolinium-containing contrast agent that is used in MRI examinations of the brain, spine, and other parts of the body. It is also used t Gadavist side effects. Get emergency medical help if you have signs of an allergic reaction to Gadavist: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Some side effects of Gadavist may occur up to several days after injection. Gadobutrol can cause a life-threatening condition in people with advanced kidney disease Occasional confounded cases of NSF have occurred in patients receiving ProHance® (gadoteridol), MultiHance® (gadobenate), Dotarem® (gadoterate), and Gadavist® (gadobutrol). However, these patients all received two or more different gadolinium compounds and hence causation by a single agent could not be established

Dotarem is a gadolinium-based contrast agent (GBCA) that helps radiologists see abnormalities on images of the central nervous system (CNS), the part of the body that contains the brain and spine, and surrounding tissues 1726 October Special Issue 2009 radiographics.rsna.org Introduction Contrast agents currently available for magnetic resonance (MR) imaging of the liver can be di-vided into five categories: (a) extracellular fluid agents, (b) hepatobiliary-specific agents, (c) com- bined agents, (d) reticuloendothelial agents Dotarem: Macrocyclic ionic: Extracellular: Gadobutrol: Gadavist/Gadovist: Macrocyclic nonionic: Extracellular: Gadoteridol: ProHance: Macrocyclic nonionic: Extracellular: Macrocyclic vs Linear Gadolinium-based Contrast Agents There are 2 structurally distinct categories of commercially available GBCAs: linear (open chain) or macrocyclic.. Eovist Properties Gadoxetate Gd-EOB-DTPA Eovist®, Primovist® Linear; weak protein binding = double relaxivity. 1 mL = 1 mmol 50% biliary elimination 10 or 20 mL (0.025 - 0.05 mmol/kg; 25% - 50% dose

Gadopiclenol resulted in twofold higher DCNR at 0.1 mmol/kg (P, .001 vs gadobutrol and gadoterate, P = .002 vs gadobenate) and similar DCNR at 0.05 mmol/kg (P = .56, P > .99, and P = .44 compared with gadobutrol, gadobenate, and gadoterate, respectively). For both readers, 0.05 mmol/kg of gadopiclenol improved contrast enhancement, borde DESCRIPTION. Gadavist (gadobutrol) injection is a paramagnetic macrocyclic contrast agent administered for magnetic resonance imaging.The chemical name for gadobutrol is 10-[(1SR,2RS)-2,3-dihydroxy-1- hydroxymethylpropyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid, gadolinium complex

Dotarem: - Discard if product has been frozen - Discard product if it contains particulate matter, is cloudy, or discolored - Discard unused portion. Do not store for later use. - Do not freeze - Store at 77 degrees F; excursions permitted to 59-86 degrees Gadolinium contrast agents help improve the quality of MRI scans. Side effects include nephrogenic systemic fibrosis (NSF) which is associated with the administration of intravenous gadolinium. Risk factor is acute or chronic renal failure. Informed consent should be obtained by the radiologist if intravenous gadolinium is to be given to high risk patients

Gadoteric acid, sold under the brand name Dotarem among others, is a macrocycle-structured gadolinium-based MRI contrast agent (GBCA).It consists of the organic acid DOTA as a chelating agent, and gadolinium (Gd 3+), and is used in form of the meglumine salt (gadoterate meglumine). The paramagnetic property of gadoteric acid reduces the T1 relaxation time (and to some extent the T2 and T2. Comparing Dotarem vs Gadobutrol. View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions. Gadavist: Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. 15.1 hours. 2.13 hours

FDA Drug Safety Communication: FDA warns that gadolinium

Macrocyclic gadolinium contrast agents include products like Gadavist, ProHance and Dotarem. Researchers collected data on patients who underwent contrast-enhanced MRI scans using Dotarem and. Gadavist Gadobutrol Macrocyclic nonionic II Dotarem Gadoterate meglumine Macrocyclic ionic II Clariscan Gadoterate meglumine Macrocyclic ionic II Eovist Gadoxetate disodium Linear ionic III Note: Group I: gadolinium-based contrast media (GBCM) associated with the greatest number of nephrogenic systemic fibrosis (NSF) cases. Group

The Debate Over Gadolinium MRI Contrast Toxicit

  1. Dotarem (gadoterate) Eovist (gadoxetic acid) Gadavist (gadobutrol) In practice, gadolinium-based contrast agents are commonly referred to as gad or gado by MRI technologists. Verywell / Cindy Chung Possible Risks MRI is generally considered safer than imaging procedures that expose you to ionizing radiation
  2. On the other hand, whereas all the macrocyclic agents (Dotarem, Gadavist, and ProHance) and the substituted linear agent MultiHance, are approved for use in children older than 2 years of age, only Dotarem, Gadavist, and MultiHance have a neonate indication. 7-10 Among these agents, MultiHance is unique in possessing higher r1 relaxivity.
  3. e), Gadavist (gadobutrol), and ProHance (gadoteridol). Related Articles New Study Sheds Light on Safety of.
  4. e injection) is a macrocyclic contrast agent. Guerbet LLC manufacturers the drug, which first hit the market in 2013. It is FDA-approved for MRI imaging of the brain, spine and associated tissues in adults and children including newborns. Gadavist (gadobutrol) is a macrocylic contrast agent manufactured by Bayer.
  5. istration (FDA) has updated a safety bulletin about gadolinium-based contrast agents (GBCAs), after studies raised new concerns about them. Doctors often use GBCAs to.

The use of gadolinium in patients with contrast allergy or

  1. Gadobutrol (also known as Gadovist/Gadavist TM) is an extracellular intravenous contrast agent used in magnetic resonance imaging.. cyclic, non-ionic molecule 100% renally excreted; T1 relaxivity @ 1.5 T: 4.9-5.5 (slightly higher than other extracellular contrast agents
  2. The study was conducted to gain knowledge about a new dose of a diagnostic drug that is used for contrast-enhanced Magnetic Resonance Imaging (MRI) of the human central nervous system (CNS). MRI can visualize the anatomy of the body and is used to detect medical conditions. Diagnostic drugs like gadobutrol and gadoterate contain an element called gadolinium that is applied to improve the.
  3. The FDA adds: Gadolinium stays in the body more after Omniscan or Optimark than after Eovist, Magnevist, or MultiHance. Gadolinium stays in the body the least after Dotarem, Gadavist, or ProHance. Reported side effects. Gadolinium-based contrast agents have been used in MRI for over 30 years now
  4. e, marketed as Dotarem by Guerbet Pharmaceuticals (Villepinte, France) is a macrocyclic, ionic agent. 53,54 This agent was approved by Health Canada in 2016 40 but has been in clinical use in Europe for many years
  5. e) 0.5 mol/L 6 Omniscan (gadodiamide) 0.5 mol/L 7 Multihance (gadobenate dimeglu
  6. e (Magnevist, n = 899), Gadobutrol (Gadovist/Gadavist, n = 95), Gadodiamide (Omniscan, n = 31), Gadobenate dimeglu

Dotarem (gadoterate meglumine) Eovist (gadoxetate disodium) Gadavist (gadobutrol) Magnevist (gadopentetate dimeglumine) MultiHance (gadobenate dimeglumine) Omniscan (gadodiamide The standard dose at UW for this off-label application is 3.0 mg/kg. Contrast Agent: gadobenate dimeglumine (MultiHance) - 0.5 M gadoxetic acid (Eovist) - 0.25 M gadoterate meglumine (Dotarem) - 0.5 M gadoteridol (Prohance) - 0.5 M gadopentatate dimeglumine (Magnevist) - 0.5 M gadodiamide (Omniscan) - 0.5 M gadobutrol (Gadavist) - 1 M.

Gadolinium contrast agents - Questions and Answers in MR

  1. ProHance Gadavist Dotarem 0 5 10 15 20 G d c o n c e n t r a t i o n (mg G d / g t i s s u e) Basal Ganglia 6 34 6 34 6 34 6 34 6 34 6 34 6 34 6 34 0 5 10 15 20 G d c o n c e n t r a t i o n (mg G d / g t i s s u e) Dentate 0.0 0.2 0.4 0.6 6 34 6 34 6 34 6 34 0.0 0.2 0.4 0.6 Macrocyclic vs. Linear GBCAs. Gadolinium Retention EMA AND FDA.
  2. DOTAREM ® (doh TAH rem) Gadolinium stays in the body the least after Dotarem, Gadavist or ProHance. • People who get many doses of gadolinium medicines, women who are pregnant and young children may be at increased risk from gadolinium staying in the body
  3. The lowest retention is seen in Dotarem, Gadavist, and ProHance. Health care providers are required to advise patients that gadolinium can be retained in the brain, bones, or organs of patients with normal renal function for months or years. Gadolinium Dyes
  4. e) is a radioactive contrast agent injected into people prior to an MRI scan. The way the substance reacts to the magnetic field of the MRI, allowing doctors to see various anatomical features and problems though non-invasive imaging
  5. e) with a unique profile, providing the highest molecular stability to

Gadobutrol (Gd-DO3A-butrol) is a gadolinium-based MRI contrast agent (GBCA).. It received marketing approval in Canada and the United States. As of 2007, it was the only GBCA approved at 1.0 molar concentrations.. Gadobutrol is marketed by Bayer AG as Gadovist, and by Bayer HealthCare Pharmaceuticals as Gadavist.. In India, it is also marketed by Vivere Imaging as Viv-butrol agent. Gadavist (gadobutrol) is another relatively new agent and this agent has twice the concentration of gadolinium (1M) vs the other agents (0.5M). I have used it, but I have limited experience with this agent. We often use half dose in patients with renal dysfunction, and for most agents, this translates to half volume. When it comes to Ga Gadoxetate disodium (also known by the tradenames Primovist TM and Eovist TM) is a hepatospecific paramagnetic gadolinium-based contrast agent, used exclusively in MRI liver imaging.. Its chief use is in hepatic lesion characterization, i.e. assessing focal liver lesions identified on other imaging studies Gadobutrol (Gadavist, Bayer Pharma) and gadoterate meglumine (Dotarem, Guerbet) were evaluated at equivalent (mmoL/kg) doses using both time resolved and non-dynamic MRA techniques in 12 experimental animals (swine) with bilateral renal artery stenoses in this IACUC approved study For all readers in the REMIND Study, more than 90% of patients presented with good or excellent overall lesion visualization and characterization with either Dotarem ® or Gadavist ®. 1 Dotarem ® is not only trusted for high molecular stability 2,3 ; the REMIND Study demonstrates that it is as effective as Gadavist ® for MRI diagnosis of.

In multiple randomized clinical studies, MultiHance ® (gadobenate dimeglumine) injection, 529 mg/mL demonstrated significantly improved visualization and contrast enhancement of CNS lesions when compared with Gadavist ®, Dotarem ®, Magnevist ®, and Omniscan TM. 1-4. Figure 1. MultiHance (gadobenate dimeglumine) injection, 529 mg/mL vs. Gadolinium-based contrast medium can cause a condition known as nephrogenic systemic fibrosis (NSF) in patients with severely reduced kidney function. Severely reduced function is usually determined by a blood test called an estimated glomerular filtration rate (eGFR). If your eGFR is 30 mL/min or below, or you are seriously unwell and your.

Dotarem, Gadavist, or ProHance. People who get many doses of gadolinium medicines, women who are pregnant and young children may be at increased risk from gado- linium staying in the body. Some people with kidney problems who get gadolinium medicines can develop a condition with severe thickening of the skin, muscle In a systematic review and meta-analysis of 9 studies, including 716,978 GBCA administrations, rates of immediate allergic-like AEs per 10,000 administrations among macrocyclic agents were lowest for ionic Dotarem® vs nonionic Gadavist® and ProHance ®. 1

Video: Dotarem: A safe(r) gadolinium-based contrast imaging agent

Contrast Medium: Using Gadolinium or Iodine in Patients

Bussi et al. compared Gd levels in blood, cerebrum, cerebellum, liver, femur, kidneys, and skin after multiple exposures of rats to DOTAREM, Gadavist ®, and ProHance ®, and found that at 28 days (4 weeks), there was less Gd retention with ProHance than with DOTAREM or Gadavist in most tissues.However, DOTAREM had significantly less Gd presence in the femur, where higher levels of Gd. Gadolinium-Based Contrast Agents and Brain Safety: Signal vs Noise. Tricia Ward. Disclosures. June 26, 2017. 3 Read Comments. Gadolinium-based contrast agents (GBCAs) used in MRI and angiography. September 6, 2017 — Guerbet LLC USA announced that the U.S. Food and Drug Administration (FDA) has approved Dotarem (gadoterate meglumine) for intravenous use with magnetic resonance imaging (MRI) in pediatric patients under two years old, including term neonates. The contrast agent can be used to detect and visualize areas with disrupted blood brain barrier and/or abnormal vascularity of.

NSF has also been reported with Gadavist and Prohance - non-ionic macrocyclic agents. No case of NSF has been reported with Dotarem, an ionic macrocyclic agent, but this may be because we just haven't used this agent for long enough. On incidence of NSF alone, Omniscan, Optimark, and Magnevist can be singled out in ESKD Gadavist (gadobutrol) is another relatively new agent and this . agent has twice the concentration of gadolinium (1M) vs the other . patients, even with a macrocyclic agent, in this case Dotarem (gad-oterate meglumine). 31. Presently, the FDA has indicated that the use of

If you have advanced kidney disease there is a well known risk of developing a very serious disease known as nephrogenic systemic fibrosis. This disease has nearly disappeared in the medical field by avoiding the use of gadolinium contrast in patients with poor kidney disease Dotarem was already widely used in Europe and other countries around the world . Dotarem vs Gadovist - Comparison Of Side Effects & Use . Linear gadolinium contrast agents are typically older, and include products like Magnevist, MultiHance, Omniscan and Eovist. Macrocyclic gadolinium contrast agents include products like Gadavist,. The FDA has granted expanded indications for use of gadobutrol (Gadavist; Bayer) injection, permitting its use in cardiac MR to assess myocardial perfusion and late gadolinium enhancement in adults with known or suspected coronary artery disease. Bayer, which announced the approval yesterday, notes that gadobutrol now becomes the first and only contrast agent to be approved for use in cardiac MR Gadovist ® is an extracellular, neutral macrocyclic (gadolinium (Gd) complex) MRI contrast agents for central nervous system indications, particularly suited for studies in which high doses are required or advantageous. Gadovist ® (also Gadograf) was available in two concentrations, currently only Gadovist ® 1.0 is marketed. The product was approved in Switzerland in 1999 and in Germany in.

MRI Contrast Agents - Side Effects of Magnevist and Omnisca

201221 GADOVIST 1.0 DS Page 1 of 19 NEW ZEALAND DATA SHEET 1. PRODUCT NAME GADOVIST® 1.0 (1.0 mmol/mL) Solution for Intravenous Injection. 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Gadobutrol 604.72 mg/mL (1.0 mmol/mL Gadavist is a sterile, clear, colorless to pale yellow solution containing 604.72 mg gadobutrol per mL (equivalent to 1 mmol/mL) as the active ingredient and the excipients calcobutrol sodium, trometamol, hydrochloric acid (for pH adjustment) and water for injection. Gadavist contains no preservatives Gadovist vs dotarem. Gadovist vs magnevist. Gadovist vs gadolinium. Gadovist vs multihance. Compare Search ( Please select at least 2 keywords ) Most Searched Keywords. Ludwig rocker snare drum reviews 1 . Variability in statistics definition 2 . Freezerless compact refrigerator at walmart 3 AuntMinnieEurope.com is the largest and most comprehensive community Web site for medical imaging professionals worldwide. Radiologists, technologists, administrators, and industry professionals can find information and conduct e-commerce in MRI, mammography, ultrasound, x-ray, CT, nuclear medicine, PACS, and other imaging disciplines MultiHance is a sterile, nonpyrogenic, clear, colorless aqueous solution for intravenous use only, containing 529 mg gadobenate dimeglumine per mL. MultiHance is contraindicated in patients with known allergic or hypersensitivity reactions to gadolinium-based contrast agents [see Warnings and Precautions (5.2)]

Guerbet reveals its Purpose, a strategic guide for its action and decisions Guerbet North America Welcomes New Compliance Counsel Producing Solutions in the U.S. for U.S. Healthcare Providers Guerbet Issues Letter on Coronavirus Pandemic Guerbet Services Teams Are Mobilized to Support Healthcare Professionals During Covid-1 Eovist ® is the only FDA-approved Hepatobiliary Specific Contrast Agent (HBA) for MR liver imaging. 1,2 It is a bi-phasic contrast agent combining dynamic phase imaging (similar to extracellular agents) along with functional, hepatobiliary phase information 3 to support your comprehensive evaluation of focal liver disease least after Dotarem, Gadavist, or ProHance. Some people can feel pains, tiredness, and skin, muscle or bone ailments for a long time. These conditions have not been directly linked to GBCAs. People who get many doses, women who are pregnant, and young children may be at increased risk. Consider retentio eGFR must be less than 2 days old and > 30. If eGFR is < 30 Radiologist needs to consent. Patient getting higher than standard dose (ie. Double dosing) of group II/III agent (such as Dotarem or Eovist) per protocol (ex. Some Cardiac MRI exams, Gamma-Knife Met protocol brain MRI) require renal function screening as a larger dose of Gadolinium is.

Macrocyclic MR contrast agents: evaluation of multiple

Two of them, Dotarem and Gadavist, have been tested on patients who need repeat MRI scans; there is no evidence that deposits are left behind. Dotarem, which was approved by the FDA in 2013, is so safe that even children who require brain scans with contrast show no evidence of residue in brain tissue or elsewhere. To date, Dotarem appears safe. Macrocyclic GBCAs - Dotarem is a macrocyclic ionic GBCA. ProHance and Gadavist are macrocyclic nonionic agents. ProHance and Dotarem have the highest combined thermodynamic and kinetic stability, reflecting the greater energy and time required to remove the Gadolinium ion from the ring structure in which it is held On the other hand, case 2 received the last dose of Gadavist 392 in rats which found a clear difference in T1 SI changes in the deep cerebellar nuclei with repeated doses of Omniscan vs. no change in SI with Dotarem compared with saline injected control animals. ICP-MS measures in these rats showed high levels of Gd in cerebellar nuclei at. -Multihance > Gadavist > others -Others= Magnevist, Prohance, Omniscan, Dotarem • Volumetric imaging -1 acquisition and can look at brain in many planes •Axial, sagittal, and coronal. Utility of Enhancement • Determine treatment effect vs tumor -Treatment necrosis has LOW perfusio The gadolinium contrast agents that leave the least amount of gadolinium behind are Dotarem, Gadavist, and Prohance, and I would certainly tell you to request one of those. Since the lesion is so small, you could track its size with non-gadolinium MRIs to see if it grows over time

Article - Considerations in the Selection of a New

Contrary to the opinions expressed on many sites on the WEB, gadolinium contrast agents are not completely excreted from the body and can cause tissue injury. At least some of these contrast agents (a number of different compounds are used) deposi.. Bad reaction to dotarem/gadolinium during MRI. When they injected me with contrast for the MRI, I ended up having almost like a burning/beating sensation up and down my left arm. It felt like someone was smacking my left arm with a hammer and the whole process left my arm feeling tender from my shoulder joint down to just north of my wrist Inaugural consensus statements were developed and endorsed by the American College of Radiology (ACR) and National Kidney Foundation to improve and standardize the care of patients with kidney disease who have indication(s) to receive ACR-designated group II or group III intravenous gadolinium-based contrast media (GBCM). The risk of nephrogenic systemic fibrosis (NSF) from group II GBCM in. FDA warns about risk of gadolinium brain deposits following MRI contrast scans study. Posted July 31, 2015 by Michael Heygood. The Food and Drug Administration has issued a warning that magnetic resonance imaging (MRI) scans using gadolinium-based contrast agents may cause metal deposits in the brain that can lead to lasting health consequences

GBCAs that are more stable chelates by virtue of macrocyclic design (gadoteridol [ProHance, Bracco], gadobutrol [Gadavist, Bayer HealthCare], and gadoterate meglumine [Dotarem, Guerbet]) or that have additional hepatobiliary elimination while being ionic linear agents (gadoxetate disodium [Eovist, Bayer HealthCare; Primovist, Bayer Schering. The aim of the study was to evaluate the acute adverse events rate and enhancement properties of gadoterate meglumine (Dotarem®) and gadobenate dimeglumine (MultiHance®) in a small-scale controlled double-blinded study, using inter- and intra-individual comparisons. Forty-one randomly selected patients were scanned with Dotarem®. The rate of adverse reactions, qualitative and quantitative. • Administer Gadavist as two (2) separate bolus injections: 0.05 mL/kg (0.05 mmol/kg) body weight at peak pharmacologic stress followed by 0.05 mL/kg (0.05 mmol/kg) body weight at rest. • Administer Gadavist via a power injector at a flow rate of approximately 4 mL/second and follow each injectio It is becoming more and more common to use MRI without contrast for screening purposes. 1. It's very accurate ''magnetic resonance imaging (MRI) should be the first-line investigation in appropriately selected patients. Where non-contrast high-res..

Gadolinium is a heavy metal that is used as a contrast agent (dye) to enhance the quality of the images obtained during an MRI or MRA scan. It is injected into the patient's vein during the scan procedure. Gadolinium contrast is supplied under various names. These include Ablavar®, Dotarem®, Clariscan®, Omniscan®, MultiHance. Absence of potential gadolinium toxicity symptoms following 22,897 gadoteric acid (Dotarem®) examinations, including 3,209 performed on renally insufficient individuals. Eur Radiol 2019; 29:1922-1930. Zhang HL, Ersoy H, Prince MR. Effects of gadopentetate dimeglumine and gadodiamide on serum calcium, magnesium and creatinine measurements. J.

Dotarem (Gadoterate, Gd-DOTA) Gadavist (USA)/Gadovist (Europe, Canada) (Gadobutrol, Gd-BT-DO3A) ProHance (Gadoteridol, Gd-HP-DO3A) Gadolinium Release and Nephrogenic Systemic Fibrosis A concept that is important in stability of gadolinium chelates in vivo is transmetalation. This is the process of gadolinium release through replacement by other. The new GBCA medication guides were one of the results of a December 19, 2017, FDA safety alert that gave the drug a new class warning. The safety agency has a long history with gadolinium, dating back to 2010 when they first highlighted possible problems from gadolinium for those with kidney failure. The FDA issued the December 2017 safety. When you say allergic to contrast, iodine, shellfish - you are referring to the contrast given for Xrays, which does contain iodine - and yes, this kind of allergy can cause death. The contrast used in MRIs is gadolinium which is NOT iodine. Allergy to it is unusual, but it does occur. Still some MRI centers ask if people are allergic to idodine, shellfish etc